Protein–DNA interactions are essential for the regulations of many important
cellular processes and single mutations occurring in DNA-binding protein have profound effect on
protein-DNA interactions and are related with many diseases. F-ProD Web Server provides fast and
accurate predictions for the effects of single amino acid substitution on the binding free energy of
protein-DNA complex. This method utilizes modified molecular mechanics Poisson-Boltzmann Surface
Area (MM/PBSA) approach along with an additional set of knowledge-based terms delivered from
investigation of the physico-chemical properties of protein-DNA complexes and results in good
agreement with experimental data.
If the usage of the server results in scientific publication, please, cite the
following papers: Link
F-ProD is running on Clemson University's Palmetto Supercomputer Cluster.
If you experience problems, they may be due to Palmetto Cluster being not functional or under
maintenance. Contact us at email@example.com.